GDNF polyclonal Antibody | BS90569

GDNF polyclonal Antibody | BS90569 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB FC

Application Range: WB:1:500-1:1,000 FC:1:50-1:200 ICC:1:50-1:200 IHC:1:50-1:200

Background: Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated, disulfide-bonded homodimer and is a distantly related member of the TGFβ superfamily of growth regulatory ligands. GDNF contains the seven conserved cysteine residues in the same relative spacing characteristic of all members of the TGFβ superfamily. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings, it has been suggested that GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: GDNF polyclonal Antibody detects endogenous levels of GDNF protein.

Molecular Weight: 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hGDNF, ATF, GDNF, Astrocyte derived trophic factor, Astrocyte derived trophic factor 1, Astrocyte-derived trophic factor, ATF 1, ATF 2, Atf, ATF1, ATF2, gdnf, GDNF, Glial cell derived neurotrophic factor, Glial Cell Line Derived Neurotrophic Factor, Glial cell line-derived neurotrophic factor, Glial derived neurotrophic factor, HFB1 GDNF, hGDNF, HSCR3,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: