GGTI-298 Trifluoroacetate | B3110

GGTI-298 is an inhibitor of geranylgeranyltransferase I. This enzyme transfers geranylgeranyl group to proteins containing a CAAX sequence in which X is leucine or isoleucine. GGTI-298 inhibits the growth of A549 cells with an IC₅₀ value of 4 μM. It induces apoptosis and blocks cells in G₀-G₁ phase.

GGTI-298 is an inhibitor of geranylgeranyltransferase I. This enzyme transfers geranylgeranyl group to proteins containing a CAAX sequence in which X is leucine or isoleucine. GGTI-298 inhibits the growth of A549 cells with an IC₅₀ value of 4 μM. It induces apoptosis and blocks cells in G₀-G₁ phase.

B3110 | GGTI-298 Trifluoroacetate DataSheet

Alternate Name/Synonyms: methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate;2,2,2-trifluoroacetic acid; (S)-methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate 2,2,2-trifluoroacetate

Appearance: White to off-white solid powder

Formulation:

CAS Number: 1217457-86-7

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₉H₃₄F₃N₃O₅S

Molecular Weight: 593.66

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of geranylgeranyltransferase I

MDL Number:

PubChem CID: 16078971

SMILES: CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC3=CC=CC=C32.C(=O)(C(F)(F)F)O

InChi: InChI=1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1

InChi Key: WALKWJPZELDSKT-UFABNHQSSA-N