GHBP, human recombinant | 4972

GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.

4972 | GHBP human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: GHR, GHBP, GH receptor, Somatotropin receptor

Alternates names: Apolipoprotein E4, APOE, apolipoprotein, apolipoproteins

Taglines: A carrier protein for growth hormone

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #:

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 90%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 34.4 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO.

Reconstitution Instructions: Reconstitute in dHO to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A