GIBH-130 | B2071

GIBH-130 is a neuroinflammation inhibitor. GIBH-130 that significantly suppresses the IL-1β secretion by activated microglia. Suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC₅₀ = 3.4 nM).

GIBH-130 is a neuroinflammation inhibitor. GIBH-130 that significantly suppresses the IL-1β secretion by activated microglia. Suppresses the proinflammatory cytokine production in LPS-stimulated N9 microglial cells (IC₅₀ = 3.4 nM).

B2071 | GIBH-130 DataSheet

Alternate Name/Synonyms: (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2-ylpiperazin-1-yl)methanone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1252608-59-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₀N₆O

Molecular Weight: 360.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A neuroinflammation inhibitor.

MDL Number: N/A

PubChem CID: 50938773

SMILES: CC1=CC(=NN=C1C(=O)N2CCN(CC2)C3=NC=CC=N3)C4=CC=CC=C4

InChi: InChI=1S/C20H20N6O/c1-15-14-17(16-6-3-2-4-7-16)23-24-18(15)19(27)25-10-12-26(13-11-25)20-21-8-5-9-22-20/h2-9,14H,10-13H2,1H3

InChi Key: ZTJHTEHADIHZJS-UHFFFAOYSA-N