GJ-103 Sodium salt | B1842

GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. It induces ATM kinase activity in A-T cells carrying different homozygous nonsense mutations; this analog is also active in A-T cells containing TAG or TAA stop codons.

GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. It induces ATM kinase activity in A-T cells carrying different homozygous nonsense mutations; this analog is also active in A-T cells containing TAG or TAA stop codons.

B1842 | GJ-103 Sodium salt DataSheet

Alternate Name/Synonyms: 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetate sodium

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1459687-96-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₆H₁₃N₄NaO₃S

Molecular Weight: 364.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An active, water-soluble analog of the read-through compound GJ072.

MDL Number: N/A

PubChem CID: 71748052

SMILES: COC1=CC=CC(=C1)N2C(=NN=C2SCC(=O)[O-])C3=CC=CC=N3.[Na+]

InChi: InChI=1S/C16H14N4O3S.Na/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22;/h2-9H,10H2,1H3,(H,21,22);/q;+1/p-1

InChi Key: PTFQBXAUOWUATD-UHFFFAOYSA-M