GJB2 Antibody | 8031

GJB2 Antibody | 8031 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Rat: (94%) , Mouse: (94%) , Sheep: (88%) , Bovine: (88%) , Chicken: (82%)

Immunogen: GJB2 antibody was raised against a 16 amino acid peptide near the center of human GJB2.
The immunogen is located within amino acids 80 - 130 of GJB2.

Research Area: Homeostasis

Tested Application: E, WB

Application: GJB2 antibody can be used for detection of GJB2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: GJB2 antibody is human specific.

Positive Control 1: Cat. No. 1320 - Human Colon Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 25 kDa
Observed: 26 kDa

Validation: N/A

Isoform: N/A

Purification: GJB2 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: GJB2 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: GJB2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Gap junction beta-2 protein, connexin 26, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The Gap junction beta-2 protein (GJB2) , also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1) . Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2) . Other mutations in this gene have also been linked to a wide array of skin diseases (3) .