GKT-137831 | 9444

GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100–150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a potent inhibitor of fibrosis and hepatocyte apoptosis.

GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100–150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a potent inhibitor of fibrosis and hepatocyte apoptosis.

9444 | GKT-137831 DataSheet

Alternate Name/Synonyms: 2-​(2-​chlorophenyl)-​4-​[3-​(dimethylamino)phenyl]-​5-​methyl-​1H-​pyrazolo[4,​3-​c]pyridine-​3,​6(2H,​5H)-​dione

Appearance: Light yellow to yellow solid

Formulation: N/A

CAS Number: 1218942-37-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C21H20ClN4O2

Molecular Weight: 394.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Nox4 and Nox1 inhibitor

MDL Number: N/A

PubChem CID: 58496428

SMILES: CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl

InChi: InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3

InChi Key: RGYQPQARIQKJKH-UHFFFAOYSA-N