GLI1 Antibody (N-Term) [ApR04957G]

GLI1 Antibody (N-Term) [ApR04957G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This GLI1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 196-230 amino acids from human GLI1.

Cellular Localisation: Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483) . Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483) . Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745) . Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441)

Molecular Weight: 117904

Clone: Polyclonal

Gene Name: GLI1

Gene ID: 2735

Function: Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340) . Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340) . Regulates the transcription of specific genes during normal development (PubMed:19706761) . Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407) . Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407) .

Summary: Tissue Location: Detected in testis (at protein level) (PubMed:2105456) . Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745) . Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Zinc finger protein GLI1, Glioma-associated oncogene, Oncogene GLI, GLI1, GLI