GLI2 Antibody (C-term) [APG03332G]

GLI2 Antibody (C-term) [APG03332G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GLI2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1287-1321 amino acids from the C-terminal region of human GLI2.

Cellular Localisation: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0VGT2}. Note=STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus {ECO:0000250|UniProtKB:Q0VGT2} [Isoform 2]: Nucleus

Molecular Weight: 167783

Clone: Polyclonal

Gene Name: GLI2 (HGNC:4318)

Gene ID: 2736

Function: Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916) . Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597) . May also function as transcriptional repressor (By similarity) . Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856) .

Summary: Tissue Location: Expressed in breast cancers (at protein level) (PubMed:26565916) . Isoform 1 and isoform 4 are expressed in HTLV-1- infected T-cell lines (at protein level) (PubMed:9557682) . Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines (PubMed:9557682) . Isoform 3 and isoform 4 are weakly expressed in HTLV- 1-infected T-cell lines (PubMed:9557682) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: IHC-P-Leica, IF, WB, FC

Dilution: WB--1:2000

Synonyms: Zinc finger protein GLI2, GLI family zinc finger protein 2 {ECO:0000312|HGNC:HGNC:4318}, Tax helper protein, GLI2 (HGNC:4318)