GLI2 monoclonal Antibody | MB63417

GLI2 monoclonal Antibody | MB63417 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse

Application: WB

Application Range: WB 1:2000

Background: This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: GLI family zinc finger 2

Molecular Weight: 167.6 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CJS; HPE9; PHS2; THP1; THP2

Immunogen: Human recombinant protein fragment corresponding to amino acids 729-1123 of human GLI2 (NP_005261) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A