Gli3 polyclonal Antibody | BS90576

Gli3 polyclonal Antibody | BS90576 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:100

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-3 (GLI family zinc finger 3), also known as GLI3FL (GLI3 full length protein), PHS, ACLS, GCPS, PAPA, PAPB, PAPA1 or PPDIV, is a 1,580 amino acid nuclear and cytoplasmic protein that acts as both a transcriptional activator and a repressor of the Sonic hedgehog (Shh) pathway. A member of the GLI C2H2-type zinc-finger protein family, GLI-3 is encoded by a gene that maps to human chromosome 7p14.1. Defects in the GLI-3 gene are the cause of a disorder known as Greig cephalo-poly-syndactyly syndrome (GCPS), which affects limb and craniofacial development.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Gli3 polyclonal Antibody detects endogenous levels of Gli3 protein.

Molecular Weight: 190 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: GLI3-190, GLI3FL, GLI3-83, GLI3, ACLS, DNA binding protein, GCPS, Gli 3, GLI family zinc finger 3, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI Kruppel family member GLI3, GLI3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3, GLI3FL, Glioma associated oncogene family zinc finger 3, Oncogene GLI3, PAP A, PAPA 1, PAPA, PAPA1, PAPB, PHS, PPD IV, PPDIV, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3, Zinc finger protein GLI3,

Immunogen: Recombinant protein within human Gli3 aa 1300-1600.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: