Description
Cell-permeable. An anti-diabetic agent. ATP-sensitive potassium channel (KATP) blocker. Inhibits KATP currents in the pancreatic beta cells causing an increase in intracellular Ca2+ and insulin secretion.
Glibenclamide is an anti-diabetic agent. ATP-sensitive potassium channel (KATP) blocker. Inhibits KATP currents in the pancreatic beta cells causing an increase in intracellular Ca2+ and insulin secretion.
1878 | Glibenclamide DataSheet
Alternate Name/Synonyms: 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide; Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 10238-21-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₈ClN₃O₅S
Molecular Weight: 494
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (100 mM) or EtOH (5 mM)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: An anti-diabetic agent
MDL Number: MFCD00056625
PubChem CID: 3488
SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
InChi: InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
InChi Key: ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
2-8°C |
Shipping Condition: |
RT |
Shelf Life: |
36 months |