GLIS2 Antibody | 8091

GLIS2 Antibody | 8091 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: GLIS2 antibody was raised against an 18 amino acid peptide near the center of human GLIS2.
The immunogen is located within amino acids 260 - 310 of GLIS2.

Research Area: Stem Cell, Neuroscience

Tested Application: E, WB, IHC-P

Application: GLIS2 antibody can be used for detection of GLIS2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: GLIS2 antibody is human, mouse and rat reactive.

Positive Control 1: Cat. No. 1204 - K562 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 58 kDa
Observed: 60 kDa

Validation: N/A

Isoform: N/A

Purification: GLIS2 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: GLIS2 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: GLIS2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: GLIS family zinc finger 2, GLI-similar 2, neuronal krueppel-like protein, NKL, NPHP7

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: GLIS2, also known as neuronal Krueppel-like, is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family (1) . GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation (1, 2) . GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta. Mutations of GLIS2 have been suggested to be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis (3, 4) .