GLO1 | Glyoxalase I (clone 6F10) | AS21 4568

GLO1 | Glyoxalase I (clone 6F10) | AS21 4568 | Gentaur UK, US & Europe Distribution

Immunogen: Recombinant, full length mouse GLO1 UniProt: Q9CPU0 fused to GST

Host: Rat

Conjugation: N/A

Clonality: Monoclonal

Isotype: IgG2b kappa

Purity: Proprietary affinity chromatography in PBS. Contains 50 % glycerol, filter sterilized.

Format: Liquid

Tested Application: ELISA (ELISA), Immunofluorescence (IF), Western blot (WB)

Related Products: Collection of antibodies to proteins involved in Alzheimer's disease

Recommended Dilutions: 1 : 1000 (WB)

Molecular weight: 27 kDa (mouse, 29 kDa (human, simian)

Confirmed Reactivity: Human, simian, mouse

Predicted Reactivity: Species of your interest not listed? Contact us

Not reactive in: N/A

Additional Information: N/A

Background: Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.

Reconstitution: N/A

Storage: Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Alzheimer's disease

Research Area: Pathology, Alzheimer's disease