GLRB Antibody | 13-695

GLRB Antibody | 13-695 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-265 of human GLRB (NP_000815.1) .

Research Area: Neuroscience, Signal Transduction

Tested Application: WB

Application: WB: 1:1000 - 1:2000

Specificiy: N/A

Positive Control 1: U-251MG

Positive Control 2: NCI-H460

Positive Control 3: HT-1080

Positive Control 4: THP-1

Positive Control 5: Mouse brain

Positive Control 6: Mouse liver

Molecular Weight: Observed: 58kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.