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Glutaminase polyclonal Antibody | BS90586
- SKU:
- BW-BS90586
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- Usually ships in 5 working days
Description
Glutaminase polyclonal Antibody | BS90586 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC/IF IHC
Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200
Background: Glutamine is an important molecule involved in several cellular functions, including nitrogen and carbon transport, hepatic urea synthesis, renal ammoniagenesis, and gluconeogenesis. Glutamine is catabolized by either the liver-type (LGA) or kidney-type (KGA) glutaminase. KGA is mitochondrial specific protein whose expression in kidney is increased during metabolic acidosis. This process is mediated by an 8-base AU-sequence in KGA that functions as a pH-response element. The human KGA gene maps to chromosome 2, and produces three isoforms, designated KGA, GAC, and GAM, by alternative splicing. KGA is synthesized as a cytosolic protein that is transported to the mitochondria as an intermediate protein, and is further cleaved into the KGA isoform and the GAC isoform. The processing of the GAM isoform is unclear. The KGA isoform is abundant in brain and kidney, while the GAC isoform is principally expressed in cardiac muscle and pancreas. The GAM isoform is solely expressed in cardiac and skeletal muscle.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Glutaminase polyclonal Antibody detects endogenous levels of Glutaminase protein.
Molecular Weight: 65 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: GLS, AAD20, DKFZp686O15119, FLJ10358, GAC, GAM, GLS, GLS1, GLSK, Glutaminase C, Glutaminase kidney isoform, Glutaminase phosphate activated, K-glutaminase, KGA, KIAA0838, L-glutamine amidohydrolase, mitochondrial,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: