GLX-351322 | B2340

GLX-351322 is a potent NADPH oxidase-4 (NOX-4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells (IC₅₀ = 5 µM).

GLX-351322 is a potent NADPH oxidase-4 (NOX4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells (IC₅₀ = 5 µM).

B2340 | GLX-351322 DataSheet

Alternate Name/Synonyms: Ethyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]-5,6-dihydro-4H-cyclopenta-[b]thiophene-3-carboxylate,GLX351322

Appearance: Crystalline solid

Formulation:

CAS Number: 835598-94-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₂₅N₃O₅S

Molecular Weight: 431.51

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >5 mg/ml (DMSO)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A NADPH oxidase 4 (NOX-4) inhibitor

MDL Number:

PubChem CID: 2697686

SMILES: CCOC(=O)C1=C(SC2=C1CCC2)NC(=O)CN3CCN(CC3)C(=O)C4=CC=CO4

InChi: InChI=1S/C21H25N3O5S/c1-2-28-21(27)18-14-5-3-7-16(14)30-19(18)22-17(25)13-23-8-10-24(11-9-23)20(26)15-6-4-12-29-15/h4,6,12H,2-3,5,7-11,13H2,1H3,(H,22,25)

InChi Key: KEVHLTCEMHIJTQ-UHFFFAOYSA-N