β-Glycyrrhetinic acid | 9586

β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. It inhibits 15-PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Displays anti-ulcerative, anti-inflammatory, and immunomodulatory properties. In addition, β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC₅₀ values of 16.1, 19.3, 15.8, and 13.7 μM, respectively. Also protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 (NF-E2-related factor-2) and PPARγ.

β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. It inhibits 15-PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Displays anti-ulcerative, anti-inflammatory, and immunomodulatory properties. In addition, β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC₅₀ values of 16.1, 19.3, 15.8, and 13.7 μM, respectively. Also protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 (NF-E2-related factor-2) and PPARγ.

9586 | β-Glycyrrhetinic acid DataSheet

Alternate Name/Synonyms: 3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid, Enoxolone; STX352; GM1658; NSC 35347

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 471-53-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₄₆O₄

Molecular Weight: 470.68

Cell-Permeable?: Yes

Purity: ≥97% by titration

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent 15-PGDH (15-hydroxy prostaglandin dehydrogenase) inhibitor

MDL Number: MFCD00003706

PubChem CID: 10114

SMILES: CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C

InChi: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1

InChi Key: MPDGHEJMBKOTSU-YKLVYJNSSA-N