GN25 | 9430

GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner. Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. At 10 μM, GN25 significantly reduces cell proliferation in KRas mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.

GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner. Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. At 10 μM, GN25 significantly reduces cell proliferation in KRas mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.

9430 | GN25 DataSheet

Alternate Name/Synonyms: 3-​[(1,​4-​dihydro-​5,​8-​dimethoxy-​1,​4-​dioxo-​2-​naphthalenyl)thio]-​propanoic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1227401-27-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₄O₆S

Molecular Weight: 322.3

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A p53-Snail-binding inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(O)CCSC(C1=O)=CC(C2=C1C(OC)=CC=C2OC)=O

InChi: InChI=1S/C15H14O6S/c1-20-9-3-4-10(21-2)14-13(9)8(16)7-11(15(14)19)22-6-5-12(17)18/h3-4,7H,5-6H2,1-2H3,(H,17,18)

InChi Key: DIIRLGMLDOPLPV-UHFFFAOYSA-N