Description
GNA11 Antibody | 18-792 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: Recombinant protein of human GNA11
Research Area: Signal Transduction
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: BT-474
Positive Control 2: SKOV3
Positive Control 3: Mouse brain
Positive Control 4: Mouse kidney
Positive Control 5: Mouse lung
Positive Control 6: Mouse intestine
Molecular Weight: Observed: 42kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, guanine nucleotide-binding protein subunit alpha-11, g alpha-11, guanine nucleotide binding protein (G protein) , alpha 11 (Gq class) , guanine nucleotide-binding protein G (y) subunit alpha
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins) , which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11) . Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2) . Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.