GNA12 Antibody (S67) [APR16175G]

GNA12 Antibody (S67) [APR16175G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GNA12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from human GNA12.

Cellular Localisation: Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Cytoplasm. Note=CDH1 enhances cell membrane localization.

Molecular Weight: 44279

Clone: Polyclonal

Gene Name: GNA12

Gene ID: 2768

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452) . Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387) . GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity) . GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452) . Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920) . Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433) . May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Guanine nucleotide-binding protein subunit alpha-12, G alpha-12, G-protein subunit alpha-12, GNA12