GNE-9605 | B2943

GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC₅₀ of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation.

GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC₅₀ of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation.

B2943 | GNE-9605 DataSheet

Alternate Name/Synonyms: 2-N-[5-chloro-1-[(3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]pyrazol-4-yl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Appearance: A crystalline solid

Formulation:

CAS Number: 1536200-31-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₇H₂₀ClF₄N₇O

Molecular Weight: 449.83

Cell-Permeable?: False

Purity: 99.26%

Solubilities: ~20 mg/ml in in DMSO, ~1 mg/ml in methanol in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of LRRK2

MDL Number:

PubChem CID: 76328936

SMILES: CNC1=NC(=NC=C1C(F)(F)F)NC2=C(N(N=C2)C3CCN(CC3F)C4COC4)Cl

InChi: InChI=1S/C17H20ClF4N7O/c1-23-15-10(17(20,21)22)4-24-16(27-15)26-12-5-25-29(14(12)18)13-2-3-28(6-11(13)19)9-7-30-8-9/h4-5,9,11,13H,2-3,6-8H2,1H3,(H2,23,24,26,27)/t11-,13-/m0/s1

InChi Key: PUXPEQJKNAWNQA-AAEUAGOBSA-N