GNPTAB Antibody | 16-308

GNPTAB Antibody | 16-308 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-350 of human GNPTAB (NP_077288.2) .

Research Area: Cancer, Signal Transduction

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: LO2

Positive Control 2: 293T

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 144kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: GNPTA, ICD, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, GlcNAc phosphotransferase, N-acetylglucosamine-1-phosphate transferase alpha and beta subunits, UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosamine, glcNAc-1-phosphotransferase subunits alpha/beta, glucosamine (UDP-N-acetyl) -lysosomal-enzyme N-acetylglucosamine phosphotransferase, stealth protein GNPTAB

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572) . In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.