GnTα4 (H65) polyclonal Antibody | BS3069

GnTα4 (H65) polyclonal Antibody | BS3069 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Alpha 1,4-N-acetylflucosaminyltransferase (α4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan) . α4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcα1-4Galβ1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. α4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. α4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. α4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H. pylori infected patients, which suggest the involvement of α4Gn-T in defense against H. pylori infection.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GnTα4 (H65) pAb detects endogenous levels of α-1,4-N-acetylglucosaminyltransferase protein.

Molecular Weight: ~ 39 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Alpha-1;4-N-acetylglucosaminyltransferase; α4GnT; A4GNT; GnTα4; α4 GnT

Immunogen: Synthetic peptide, corresponding to amino acids 32-82 of Human GnTα4.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A