Gö 6983 | 9539

Gö 6983 is a broad-spectrum Protein Kinase C (PKC) inhibitor; inhibits several isoforms of protein kinase C with IC₅₀ values of 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively). It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.

Gö 6983 is a broad-spectrum Protein Kinase C (PKC) inhibitor; inhibits several isoforms of protein kinase C with IC₅₀ values of 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively). It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.

9539 | Gö 6983 DataSheet

Alternate Name/Synonyms: 3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione

Appearance: Red solid

Formulation: N/A

CAS Number: 133053-19-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₆N₄O₃

Molecular Weight: 442.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A broad-spectrum PKC inhibitor

MDL Number: MFCD04040031

PubChem CID: 3499

SMILES: CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

InChi: InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChi Key: LLJJDLHGZUOMQP-UHFFFAOYSA-N