Description
ADP-ribosylation factor 1 (Arf1) plays an important role in regulating secretory traffic and membrane transport within the Golgi. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs). Golgicide A is a potent, specific and reversible inhibitor of the cis-Golgi ArfGEF GBF1. Inhibition of GBF1 function results in rapid dissociation of COPI vesicle coat from Golgi membranes and subsequent disassembly of the Golgi and trans-Golgi network (TGN). Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC₅₀ of 3.3 μM in Vero cells.
ADP-ribosylation factor 1 (Arf1) plays an important role in regulating secretory traffic and membrane transport within the Golgi. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs). Golgicide A is a potent, specific and reversible inhibitor of the cis-Golgi ArfGEF GBF1. Inhibition of GBF1 function results in rapid dissociation of COPI vesicle coat from Golgi membranes and subsequent disassembly of the Golgi and trans-Golgi network (TGN). Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC₅₀ of 3.3 μM in Vero cells.
Alternate Name/Synonyms: (3aR,9bS)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline; GCA
Appearance: Off-white Solid
Formulation:
CAS Number: 1139889-93-2
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₇H₁₄F₂N₂
Molecular Weight: 284.3
Cell-Permeable?: TRUE
Purity: ≥99%
Solubilities: ~1 mg/ml in ethanol, ~30 mg/ml in DMF, ~10 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of the cis-Golgi ArfGEF GBF1
MDL Number: MFCD04128902
PubChem CID: 25113626
SMILES: C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
InChi: InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1
InChi Key: NJZHEQOUHLZCOX-FTLRAWMYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |