Gossypin | 2374

A glucoside occurring in cotton and Hubiscus flowers that acts as a potent antimelanoma agent. Gossypin inhibits human melanoma cell proliferation, in vitro, in melanoma cell lines that harbors both BRAF-V600E kinase and CDK4 as well as in cells with BRAF wild-type allele. Gossypin inhibits the kinase activities of BRAF-V600E and CDK4, in vitro, possibly through direct binding with these kinases.

Gossypin is a glucoside occurring in cotton and Hubiscus flowers that acts as a potent antimelanoma agent.

2374 | Gossypin DataSheet

Alternate Name/Synonyms: 3,3',4',5,7,8-Hexahydroxyflavone-8-glucoside

Appearance: Yellow solid

Formulation: N/A

CAS Number: 652-78-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₀O₁₃

Molecular Weight: 480.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent antimelanoma agent

MDL Number: MFCD00017429

PubChem CID: 5281621

SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O)O

InChi: InChI=1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1

InChi Key: SJRXVLUZMMDCNG-KKPQBLLMSA-N