GPNA (monohydrate) | B2150

GPNA is a substrate for γ-glutamyl transpeptidase. GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.

GPNA is a substrate for γ-glutamyl transpeptidase. GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.

B2150 | GPNA (monohydrate) DataSheet

Alternate Name/Synonyms: (L-γ-Glutamyl-p-nitroanilide, L-Glutamic acid 5-(4-nitroanilide)

Appearance: White to green yellow solid

Formulation: N/A

CAS Number: 7300-59-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₃N₃O₅.H₂O

Molecular Weight: 285.25

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A glutamine uptake inhibitor

MDL Number: MFCD00036218

PubChem CID: N/A

SMILES: O=C(Nc1ccc(cc1)[N+]([O-])=O)CC[C@H](N)C(=O)O

InChi: InChI=1S/C11H13N3O5/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17)/t9-/m0/s1

InChi Key: WMZTYIRRBCGARG-VIFPVBQESA-N