GPR124 Antibody (C-Term) [ApR04948G]

GPR124 Antibody (C-Term) [ApR04948G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GPR124 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1259-1293 amino acids from human GPR124.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Cell projection, filopodium. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact

Molecular Weight: 142647

Clone: Polyclonal

Gene Name: ADGRA2 (HGNC:17849)

Gene ID: 25960

Function: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314) . Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity) . Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314) . ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314) . Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628) .

Summary: Tissue Location: Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628) . Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: G-protein coupled receptor 124, Tumor endothelial marker 5, GPR124, KIAA1531, TEM5