GPR167 polyclonal Antibody | BS62416

GPR167 polyclonal Antibody | BS62416 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat,Mouse

Application: WB

Application Range: WB: 1:500~1000

Background: Nuclear hormone receptors function as transcriptional activators when their cognate ligands are bound. Binding of the appropriate ligand induces a conformational change in the nuclear receptor, allowing it to interact with transcriptional coactivators. NRBF2 (Nuclear receptor-binding factor 2), also known as COPR (Comodulator of PPAR and RXR), is thought to act as a transcriptional coactivator by altering the activity of target nuclear receptors. Highly expressed in the liver, placenta and keratinocytes, NRBF2 can interact with at least 7 nuclear receptors including PPARα, PPARδ and PPARγ. In the presence of a bound ligand, NRBF2 can interact with nuclear receptors RARα, RARγ. and RXRα. NRBF2, which exists as two isoforms due to alternative splicing, is localized to both the nucleus and the cytoplasm.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NRBF2 polyclonal Antibody detects endogenous levels of NRBF2 protein.

Molecular Weight: ~ 40,34,26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Nuclear receptor-binding factor 2; NRBF-2; Comodulator of PPAR and RXR; NRBF2; COPR

Immunogen: Synthetic peptide, corresponding to Human NRBF2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

Pathway: