GPR174 polyclonal Antibody | BS62427

GPR174 polyclonal Antibody | BS62427 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat,Mouse

Application: WB IHC

Application Range: WB: 1:500~1000

Background: Mitochondrial polyribonucleotide nucleotidyltransferase, also designated 3'-5' RNA exonuclease, OLD35, PNPase or PNPT1, is an evolutionaly conserved protein in which the mouse protein shares 90% identity with the human version. PNPase participates in mRNA degradation and hydrolyzes single-stranded ribonucleotides in the 3' to 5' direction. PNPase forms homotrimers and is upregulated in response to interferon-β induction. The N-terminus of PNPase contains a putative mitochondrial targeting sequence; mutation analysis confirms that N-terminal sequences of PNPase target the protein to the mitochondria. Endogenous PNPase also co-localizes with a mitochondrial marker protein in HeLa cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -24°C long term. Avoid freeze-thaw cycles.

Specificity: PNPT1 polyclonal Antibody detects endogenous levels of PNPT1 protein.

Molecular Weight: ~ 88 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Polyribonucleotide nucleotidyltransferase 1, mitochondrial; 3'-5' RNA exonuclease OLD35; PNPase old-35; Polynucleotide phosphorylase 1; PNPase 1; Polynucleotide phosphorylase-like protein; PNPT1; PNPASE

Immunogen: Synthetic peptide, corresponding to Human PNPT1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .

Pathway: