BW
GPR214 polyclonal Antibody | BS62475
- SKU:
- BW-BS62475
- Availability:
- Usually ships in 5 working days
Description
GPR214 polyclonal Antibody | BS62475 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Rat,Mouse
Application: WB IHC
Application Range: WB: 1:500~1000
Background: Serine/threonine-protein phosphatase 4 regulatory subunit 2, regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) . May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Storage & Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Specificity: PPP4R2 polyclonal Antibody detects endogenous levels of PPP4R2 protein.
Molecular Weight: ~ 55 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Serine/threonine-protein phosphatase 4 regulatory subunit 2; PPP4R2; SBBI57
Immunogen: Synthetic peptide, corresponding to Human PPP4R2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Pathway: