GPR30 Polyclonal Antibody | BS65862

GPR30 Polyclonal Antibody | BS65862 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,

Application: WB,IHC-P,

Application Range: WB=1:500-2000 IHC-P=1:100-500

Background: G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives.

Storage & Stability: Store at 4°C short term. Aliquot and store at -35°C long term. Avoid freeze-thaw cycles.

Specificity: GPR30 Polyclonal Antibody detects endogenous levels of GPR30 protein.

Molecular Weight: ~55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: G Protein Coupled Receptor 30; G-protein coupled receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen receptor; mER; Chemokine receptor-like 2; IL8-related receptor DRY12; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; Lymphocyte-derived G-protein coupled receptor; LYGPR; GPCR-BR; CEPR; CMKRL2; DRY12; GPER.

Immunogen: KLH conjugated synthetic peptide derived from human GPR30:251-350/375

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: Signaling Pathways Activating p38 MAP Kinase,