GPR37L1 Antibody (N-term) [APR12220G]

GPR37L1 Antibody (N-term) [APR12220G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GPR37L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human GPR37L1.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2}

Molecular Weight: 52771

Clone: Polyclonal

Gene Name: GPR37L1

Gene ID: 9283

Function: G-protein coupled receptor (PubMed:27072655) . Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594) . However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853) . It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G (s) subunit alpha (PubMed:27072655) . Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity) . Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity) . Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity) .

Summary: Tissue Location: Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594) . Expressed in the central nervous system (PubMed:9539149) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Prosaposin receptor GPR37L1, Endothelin B receptor-like protein 2, ETBR-LP-2, G-protein coupled receptor 37-like 1, GPR37L1, ETBRLP2