GPR52 Antibody (C-term) [APR16587G]

GPR52 Antibody (C-term) [APR16587G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GPR52 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-245 amino acids from the C-terminal region of human GPR52.

Cellular Localisation: Cell membrane; Multi-pass membrane protein.

Molecular Weight: 41354

Clone: Polyclonal

Gene Name: GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508}

Gene ID: 9293

Function: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241) . May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241) . Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228) .

Summary: Tissue Location: Expressed in brain, especially in striatum.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Probable G-protein coupled receptor 52, GPR52