LBD
GPR52 Antibody (C-term) [APR16587G]
- SKU:
- LBD-APR16587G
- Availability:
- Usually ships in 5 working days
Description
GPR52 Antibody (C-term) [APR16587G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This GPR52 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-245 amino acids from the C-terminal region of human GPR52.
Cellular Localisation: Cell membrane; Multi-pass membrane protein.
Molecular Weight: 41354
Clone: Polyclonal
Gene Name: GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508}
Gene ID: 9293
Function: Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241) . May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241) . Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228) .
Summary: Tissue Location: Expressed in brain, especially in striatum.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Probable G-protein coupled receptor 52, GPR52