GPSM2 Antibody (N-Term) [ApR04938G]

GPSM2 Antibody (N-Term) [ApR04938G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GPSM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 113-143 amino acids from human GPSM2.

Cellular Localisation: Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle pole. Lateral cell membrane. Note=Localizes in the cytoplasm during interphase and at cell cortex during metaphase (PubMed:11781568, PubMed:15632202, PubMed:22074847) . Colocalizes with NUMA1 to mitotic spindle poles (PubMed:11781568, PubMed:21816348) . Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner (PubMed:22327364) . In horizontally retinal progenitor dividing cells, localized to the lateral cortical region. In vertically retinal progenitor dividing cells, localized at the polar cortical region (By similarity) . {ECO:0000250|UniProtKB:Q8VDU0, ECO:0000269|PubMed:11781568, ECO:0000269|PubMed:15632202, ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:22074847, ECO:0000269|PubMed:22327364}

Molecular Weight: 76662

Clone: Polyclonal

Gene Name: GPSM2

Gene ID: 29899

Function: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348) . Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364) . Plays a role in metaphase spindle orientation (PubMed:22327364) . Plays also an important role in asymmetric cell divisions (PubMed:21816348) . Has guanine nucleotide dissociation inhibitor (GDI) activity towards G (i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity) .

Summary: Tissue Location: Ubiquitously expressed.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: G-protein-signaling modulator 2, Mosaic protein LGN, GPSM2, LGN