GR monoclonal Antibody | MB9238

GR monoclonal Antibody | MB9238 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB ICC IHC FC

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: GR monoclonal Antibody detects endogenous levels of GR protein.

Molecular Weight: 86 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: GR, NR3C1, GRL, GCCR, GCR, Glucocorticoid receptor alpha isoform, Glucocorticoid receptor, GR, GRL, NR3C1, Nuclear receptor subfamily 3 group C member 1,

Immunogen: Recombinant full length protein corresponding to Human Glucocorticoid Receptor alpha.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProG affinity purified.

Pathway: