LBD
GRB14 Antibody (N-Term) [APR33662G]
- SKU:
- LBD-APR33662G
- Availability:
- Usually ships in 5 working days
Description
GRB14 Antibody (N-Term) [APR33662G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This GRB14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 14-48 amino acids from the human region of human GRB14.
Cellular Localisation: Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Molecular Weight: 60988
Clone: Polyclonal
Gene Name: GRB14
Gene ID: 2888
Function: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Summary: Tissue Location: Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, FC, IF
Dilution: IF--1:25 FC--1:25 WB--1:1000
Synonyms: Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14