Gremlin 2, human recombinant | 4657

Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mos-transformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors. Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed from E. coli.

4657 | Gremlin 2 human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: Gremlin 2

Alternates names: FST, FS, Activin-binding protein

Taglines: Inhibitor of BMP-2, -4, and -7

NCBI Gene ID #: 10468

NCBI Gene Symbol: FST

Gene Source: Human

Accession #: P19883

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 31.5 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Sterile filtered and lyophilized with no additives

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A