GRK1 Antibody (C-term) [APR12283G]

GRK1 Antibody (C-term) [APR12283G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This GRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-550 amino acids from the C-terminal region of human GRK1.

Cellular Localisation: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid- anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4} Note=Subcellular location is not affected by light or dark conditions {ECO:0000250|UniProtKB:Q9WVL4}

Molecular Weight: 63526

Clone: Polyclonal

Gene Name: GRK1 (HGNC:10013)

Gene ID: 6011

Function: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941) . This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity) . May play a role in the maintenance of the outer nuclear layer in the retina (By similarity) .

Summary: Tissue Location: Retinal-specific. Expressed in rods and cones cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Rhodopsin kinase, RK, G protein-coupled receptor kinase 1, GRK1, RHOK