GRN polyclonal Antibody | BS7852

GRN polyclonal Antibody | BS7852 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Acrogranin (also designated PC cell-derived growth factor (PCDGF), epithelin/granulin precursor or paragranulin) is a glycosylated protein originally purified from the highly tumorigenic, Insulin-independent mouse teratoma PC cell line. Acrogranin is a cysteine-rich molecule whose expression is essential for tumorigenicity in teratoma cells. Acrogranin is expressed in estrogen receptor-positive (ER (+) ) human mammary MDA-MB-468 epithelial cells, human breast cancer MCF7 cells and human estrogen-responsive T-47D cells. Secreted acrogranin acts as an autocrine growth factor for breast carcinoma cells and overexpression may play an important role in human breast cancer. Acrogranin stimulates the growth of PC cells as well as 3T3 fibroblasts.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GRN polyclonal Antibody detects endogenous levels of GRN protein.

Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Acrogranin; CLN11; GEP; GP88; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin epithelin; Granulin F; Granulin G; Granulin-7; Granulins; GRN; GRN_HUMAN; PC cell derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin;

Immunogen: Recombinant full length Human GRN.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: