Growth Hormone polyclonal Antibody | BS90602

Growth Hormone polyclonal Antibody | BS90602 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IP IHC

Application Range: WB:1:1,000-1:5,000 IHC:1:50-1:200

Background: Pituitary growth hormone (GH), also designated somatotropin, plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is secreted in a pulsatile pattern which is tightly controlled by the interplay of GH-releasing hormone (GHRH) and somatostatin (SRIF) . GHRH and SRIF are the primary hypothalamic factors that determine GH secretion from the somatotroph and regulate GH synthesis and secretory reserve. GH output is also highly sensitive to feedback control by GH itself, as well as by insulin-like growth factor I. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Growth Hormone polyclonal Antibody detects endogenous levels of Growth Hormone protein.

Molecular Weight: 25 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: GH, GH-N, GH1, gH, GH-N, GH1, GHB5, GHN, Growth hormone 1, Growth hormone, Growth hormone B5, Growth hormone, normal, Growth hormone, pituitary, HG1, hGH-N, IGHD1B, Pituitary growth hormone, RNGHGP, SOMA, Somatotropin,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: