GRPR Antibody (Center) [APR32739G]

GRPR Antibody (Center) [APR32739G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 43199

Clone: Polyclonal

Gene Name: GRPR

Gene ID: 2925

Function: Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761) . Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity) .

Summary: Tissue Location: Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000-1:2000

Synonyms: Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR