GSK-046 | B3270

GSK-046 (iBET-BD2) is a potent and selective inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2BD2, BRD3BD2, BRD4BD2 and BRDTBD2, respectively. GSK-046 displays immunomodulatory activity.

GSK-046 (iBET-BD2) is a potent and selective inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2BD2, BRD3BD2, BRD4BD2 and BRDTBD2, respectively. GSK-046 displays immunomodulatory activity.

B3270 | GSK-046 DataSheet

Alternate Name/Synonyms: GSK046 iBET-BD2 4-Acetamido-3-fluoro-N-((1r,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide

Appearance: Crystalline solid

Formulation:

CAS Number: 2474876-09-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₇FN₂O₄

Molecular Weight: 414.47

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent BD2-selective inhibitor

MDL Number:

PubChem CID: 146018690

SMILES: CC(C1=CC=CC=C1)OC2=C(C(=CC(=C2)C(=O)NC3CCC(CC3)O)F)NC(=O)C

InChi: InChI=1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18?,19?/m0/s1

InChi Key: FRBRZGLUFOZRGD-YCMKEVRSSA-N