GSK-1059615 | 9450

GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.

GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.

9450 | GSK-1059615 DataSheet

Alternate Name/Synonyms: 5Z-​[[4-​(4-​pyridinyl)-​6-​quinolinyl]methylene]-​2,​4-​thiazolidinedione

Appearance: Off-white solid

Formulation: N/A

CAS Number: 958852-01-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₁₁N₃O₂S

Molecular Weight: 333.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, reversible PI3Kα inhibitor

MDL Number: MFCD18074517

PubChem CID: 23582824

SMILES: C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4

InChi: InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-

InChi Key: QDITZBLZQQZVEE-YBEGLDIGSA-N