GSK-1070916 | B1939

GSK-1070916 is a potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C with IC₅₀ value of 3.5 nM and 6.5 nM, respectively. Treatment of GSK-1070916 suppresses cell proliferation in A549 human lung cancer cells with EC₅₀ value of 7 nM.

GSK-1070916 is a potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C with IC₅₀ value of 3.5 nM and 6.5 nM, respectively. Treatment of GSK-1070916 suppresses cell proliferation in A549 human lung cancer cells with EC₅₀ value of 7 nM.

B1939 | GSK-1070916 DataSheet

Alternate Name/Synonyms: 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 942918-07-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₃N₇O

Molecular Weight: 507.63

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, reversible and ATP-competitive inhibitor of Aurora kinases B and C

MDL Number: N/A

PubChem CID: 46885626

SMILES: CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C

InChi: InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38)

InChi Key: QTBWCSQGBMPECM-UHFFFAOYSA-N