GSK-1120212 | 1960

A potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9 nM) enzymes with potential antineoplastic activity.

GSK-1120212 is a potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9 nM) enzymes with potential antineoplastic activity.

1960 | GSK-1120212 DataSheet

Alternate Name/Synonyms: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057

Appearance: Off-white solid

Formulation: N/A

CAS Number: 871700-17-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₃FIN₅O₄

Molecular Weight: 615.39

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent and selective allosteric MEK1 inhibitor

MDL Number: MFCD17215075

PubChem CID: 11707110

SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O) C)C5CC5

InChi: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11- 19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4- 7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

InChi Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N