Description
GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild type B-Raf and c-Raf with IC₅₀s of 3.2 nM and 5.0 nM, respectively.
GSK2118436 is a selective BRAF V600E inhibitor. GSK2118436 binds to Raf family kinases and inhibits their activity. It is highly selective against B-Raf V600E with IC₅₀ of 0.8 nM, compared to wild type B-Raf and c-Raf with IC₅₀s of 3.2 nM and 5.0 nM, respectively.
2800 | GSK-2118436 mesylate DataSheet
Alternate Name/Synonyms: N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, methanesulfonic acid; Dabrafenib Mesylate
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1195768-06-9
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₄F₃N₅O₅S₃
Molecular Weight: 615.67
Cell-Permeable?: Y
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A selective BRAF V600E inhibitor
MDL Number: N/A
PubChem CID: 44516822
SMILES: O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O.CS(O)(=O)=O
InChi: InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)
InChi Key: YKGMKSIHIVVYKY-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |