GSK-2606414 | 9467

GSK-2606414 is a potent and selective inhibitor of protein kinase R-like ER kinase (PERK) with IC₅₀ value of 0.4 nM. Displays >1000-fold selectivity for PERK over HR1 and PKR. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice.

GSK-2606414 is a potent and selective inhibitor of protein kinase R-like ER kinase (PERK) with IC₅₀ value of 0.4 nM. Displays >1000-fold selectivity for PERK over HR1 and PKR. GSK-2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice.

9467 | GSK-2606414 DataSheet

Alternate Name/Synonyms: 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone

Appearance: White solid

Formulation: N/A

CAS Number: 1337531-36-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₄H₂₀F₃N₅O

Molecular Weight: 451.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selctive PERK (protein kinase R-like ER kinase) inhibitor

MDL Number: N/A

PubChem CID: 53469448

SMILES: CN1C=C(C2=C1N=CN=C2N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F

InChi: InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)

InChi Key: SIXVRXARNAVBTC-UHFFFAOYSA-N